The Effect of Intravenous Magnesium Therapy on Spinalanaesthesia Produced by Bupivacaine In Pre-Eclamptic Patients

Background:Magnesium has anti-nociceptive effects and potentiates opioid analgesia following its systemic and neuraxial administration. In our study, the effect of intravenous magnesium sulphate in pre-eclamptic patients on spinal anaesthesia produced by bupivacaine was investigated. Materials and Methods:Sixty pregnant (30 normal and 30 pre-eclamptic) patients were enrolled in this study in two groups: Healthy parturients (Group A) and pre-eclampticparturients with IV MgSO4 therapy (Group B). Spinalanaesthesia was given with 12.5 mg hyperbaric bupivacaine .Onset of sensory block at T6 level, highest sensory block level, motor block characteristics, time to first analgesic request, maternal hemodynamics as well as side effects were evaluated. Results:Sensory block onset time at T6 was significantly more in group A than group B. Time to first postoperative analgesic request was significantly prolonged in Group B than in Group A. Side effects were similar in both groups. Conclusion: Treatment with IV MgSO4 in pre-eclampticparturients significantly prolonged the time to first analgesic request compared to healthy parturients.